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Cipro has been shown to cause some side effects. Talk to your health care provider if these mild reactions do not go away within a few days.

Common side effects reported from Cipro use include:

  • Nausea
  • Vomiting
  • Stomach Pain
  • Diarrhea
  • Heartburn
  • Fatigue
  • Sleepiness

This is not a complete list of adverse reactions caused by Cipro.Call your doctor immediately if you experience the following:

  • Black, tarry stools
  • Blistering, peeling, or loosening of the skin
  • Bloody or cloudy urine or decreased urination
  • Fever or chills
  • Joint or muscle pain
  • Red skin lesions, often with a purple center, or skin rashes
  • Sores, ulcers, or white spots in the mouth or on the lips
  • Severe stomach pain
  • Hives or swelling of the face, fingers, feet, or lower legs
  • Unusual bleeding or bruising
  • Unusual weight gain
  • Yellow skin or eyes

Taking Cipro has been shown to impact your tendons (cords attaching bone to your muscles). It can increase your risk of developing tendonitis or a tendon rupture, especially if you’re over 60, taking steroid medications, or have a history of tendon problems.

Cipro can interact with other medications and substances, causing potentially serious side effects or allergic reactions. Tell your doctor if you are taking muscle relaxers such as tizanidine (Zanaflex), phosphodiesterase 5 (PDE5) inhibitors such as sildenafil, anticoagulants (blood thinners), antidepressants, antipsychotics, diuretics, insulin, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.

This is not a complete list of Cipro drug interactions, so discuss any medications you’re on, even if you don’t see them listed here. Cipro can cause low blood sugar in some patients. Be wary of low blood pressure symptoms such as blurred vision, fatigue, confusion, pale skin, and cold sweats. Watch for these adverse effects if you have diabetes, and take diabetes medication orally. These could be signs of hypoglycemia and could lead to unconsciousness.

The U. S. Food and Drug Administration (FDA) has found that, while rare, fluoroquinolone antibiotics like Cipro can increase the occurrence of severe ruptures or tears in your aorta (a large artery that begins in the heart). These ruptures can lead to dangerous aortic bleeding, a heart attack, or even death, so people at risk for cardiac problems should be cautious about taking Cipro.

Be sure to tell your doctor if you have been diagnosed with or have a history of other medical conditions, including a prolonged QT interval (a rare heart problem that may cause an irregular heartbeat, fainting, or sudden death), aneurysms, kidney disease, liver disease, heart disease, myasthenia gravis (severe muscle weakness), seizures, or diabetes. Cipro can also significantly increase theophylline levels in your blood, leading to serious illness or death. This is not a comprehensive list of medical conditions that Cipro may affect, so speak with your doctor about your medical history before taking Cipro.

Cipro can cause your skin to become sensitive to sunlight or ultraviolet light, so try to avoid unnecessary sun exposure and do your best to wear protective clothing, sunglasses, or sunscreen that is SPF 15 or higher. Call your doctor if you notice redness, swelling, or blistering from sun exposure while on Cipro.

As with all prescription medication, inform the prescribing doctor about any medical conditions you have been diagnosed with and any medications or supplements you currently take before starting treatment. Antacids can reduce the amount of Cipro that your body absorbs, so be sure to take them at least 2 hours before or 6 hours after taking antacid medications.

In addition, let your doctor know if you are breastfeeding, pregnant, or planning on becoming pregnant before starting treatment with this medication.

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What is Ciprofloxacin?

Ciprofloxacin is a broad-spectrum antibiotic known for its broad-spectrum activity against a wide range of bacterial strains, including those that cause bacterial skin infections. It belongs to the quinolone antibacterial drug class and works by inhibiting bacterial DNA gyrase and topoisomerase IV, two enzymes essential for DNA replication.

Ciprofloxacin has been shown to inhibit bacterial DNA gyrase and topoisomerase IV in vitro. The antibiotic is effective against a broad range of bacterial strains, such asE. coli, Klebsiella pneumoniae, Serratia marcescens, Enterobacter cloacae, Proteus mirabilis, Shigella flexneri, Proteus vulgaris, Morganella morganii, Proteus vulgaris, Proteus vulgaris, Streptococcus spp., S. epidermidis, and Streptococcus pneumoniae. Ciprofloxacin also has antibacterial and antifungal activity against some clinically significant pathogens.

How Ciprofloxacin Works

Ciprofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV. This action is particularly effective against Gram-positive and Gram-negative bacteria. Ciprofloxacin also has anti-inflammatory and antibacterial properties that help reduce inflammation and bacterial infection severity.

Ciprofloxacin is not effective against Gram-positive bacteria such asPseudomonas aeruginosa.

How to Use Ciprofloxacin

Ciprofloxacin is usually taken orally with or without food. Your doctor may recommend regular monitoring of liver function, blood sugar, and kidney function while taking this antibiotic.

If you have any questions about the Ciprofloxacin dosage, dosage regimen, or if you’re taking any other medications, contact your doctor or pharmacist. Ciprofloxacin can be taken with or without food. However, regular follow-ups with your doctor are recommended to monitor your condition more closely.

You should complete the full course of treatment, even if you start feeling better before the antibiotics are complete.

Ciprofloxacin Side Effects

Like all medicines, Ciprofloxacin can cause side effects. Most of the time, they’re mild and temporary. If you experience any serious side effects while taking Ciprofloxacin contact your doctor immediately.

Some people may experience bone fracture or severe skin rash while taking Ciprofloxacin. These side effects are usually temporary and subside once the treatment is completed. You should avoid activities which could be hazardous if you take this medication.

If you experience signs of an allergic reaction such as rash, itching, swelling, severe dizziness, or difficulty breathing, call your doctor immediately.

Ciprofloxacin Precautions and Warnings

Before using Ciprofloxacin, tell your doctor if you have a history of kidney disease, heart disease, liver disease, anemia, bleeding or blood disorders, and certain heart conditions. Ciprofloxacin should not be used in pregnant women.

In case of accidental overdose, tell your doctor or pharmacist promptly.

If you are breastfeeding, tell your doctor immediately.

Indications

Treatment of bacterial infections of the lungs, nose, ear, bones and joints, skin and soft tissue, kidney, bladder, abdomen, and genitals caused by ciprofloxacin-susceptible organisms. Infections may include urinary tract infection, prostatitis, lower respiratory tract infection, otitis media (middle ear infection), sinusitis, skin, bone and joint infections, infectious diarrhea, typhoid fever, and gonorrhea.

Administration

May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.

Contraindication

Hypersensitivity to ciprofloxacin or other quinolones. History or risk of QT prolongation; known history of myasthenia gravis. Concomitant use with tizanidine.

Common side-effects

Vomiting, Stomach pain, Nausea, Diarrhea

Special Precaution

Patient with known or suspected CNS disorders, risk factors predisposing to seizures, or lower seizure threshold; history or risk factors for QT interval prolongation, torsades de pointes, uncorrected hypokalaemia/hypomagnesaemia, cardiac disease (e.g. heart failure, MI, bradycardia); positive family history of aneurysm disease, pre-existing aortic aneurysm or dissection and its risk factors (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, hypertension, peripheral atherosclerotic vascular disease); diabetes, previous tendon disorder (e.g. rheumatoid arthritis), G6PD deficiency. Renal and hepatic impairment. Elderly, children. Pregnancy and lactation.

Storage

Store between 20-25°C.

MedsGo Class

Quinolones

Tizanidine TID D2TID D2TID D2TID D2TID D2TID D2TID D2TID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2ID D2IDKirkland D J WY KW WY KW WY KW WY KW WY KW WY KW WY KW WY KW WY KW WY KW WY KW WY WYCiprofloxacin-susceptible organisms

Lactation

Caution in patients with lactation problems or who are breastfeeding as it may affect the absorption of the medicine. Do not take w/ dairy products unless advised to by your doctor.

History or risk of QT prolongation; known or suspected QT prolongation disorders.

Active ingredient(s)

Ciprofloxacin.

Additional Information

Ciprofloxacin, like other quinolones, is excreted in breast milk. Do not consume more than the recommended amount of ciprofloxacin w/ lactation-suppressive therapy. Do not consume this medicine if you are hypersensitive to, or have had an allergic reaction to, ciprofloxacin. Do not consume this medicine if you are taking, or have recently taken, any other quinolone antibiotic. Do not take ciprofloxacin if you are pregnant, or may become pregnant, or if you are breastfeeding without consulting your doctor. Do not give ciprofloxacin to other pregnant or breastfeeding animals.

Ophthalmic ciprofloxacin comes as a solution (liquid) to apply to the eyes. Ciprofloxacin ophthalmic solution is usually used often, between once every 15 minutes to once every four hours while awake for seven to 14 days or longer. Ciprofloxacin ophthalmic ointment is usually applied three times a day for two days and then twice a day for five days. Use ciprofloxacin ophthalmic at around the same time every day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Use ciprofloxacin ophthalmic exactly as directed. Do not use it more often than prescribed by your doctor.

You should expect your symptoms to improve during your treatment. Call your doctor if your symptoms do not go away or get worse, or if you develop other problems with your eyes during your treatment.

Use ophthalmic ciprofloxacin until you finish the prescription, even if you feel better. If you stop using ophthalmic ciprofloxacin too soon, your infection may not be completely cured and the bacteria may become resistant to antibiotics.

To instill the eye drops, follow these steps:

  1. Wash your hands thoroughly with soap and water.

  2. Check the dropper tip to make sure that it is not chipped or cracked.

  3. Avoid touching the dropper tip against your eye or anything else; eyedrops and droppers must be kept clean.

  4. While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.

  5. Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.

  6. Brace the remaining fingers of that hand against your face.

  7. While looking up, gently squeeze the dropper soa single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.

  8. Close your eye for two to three minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.

  9. Place a finger on the tear duct and apply gentle pressure.

  10. Wipe any excess liquid from your face with a tissue.

  11. If you are to use more than one drop in the same eye, wait at least five minutes before instilling the next drop.

  12. Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.

  13. Wash your hands to remove any medication.

To apply the eye ointment, follow these instructions:

  1. Avoid touching the tip of the tube against your eye or anything else; the tube tip must be kept clean.

  2. Holding the tube between your thumb and forefinger, place it as near to your eyelid as possible without touching it.

  3. Tilt your head backward slightly.

  4. With your index finger, pull the lower eyelid down to form a pocket.

  5. Squeeze a 1/2-inch (1.25cm) ribbon of ointment into the pocket made by the lower eyelid.

  6. Blink your eye slowly; then gently close your eye for one to two minutes.

  7. With a tissue, wipe any excess ointment from the eyelids and lashes. With another clean tissue, wipe the tip of the tube clean.

  8. Replace and tighten the cap right away.

Prilosec (ciprofloxacin [CIPLA])
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